Stewardship Initiatives: Indiana

ANTIMICROBIAL STEWARDSHIP STATE-WIDE RESISTANCE RESOURCES

Antimicrobial resistance usually does not arise from a single exposure to antimicrobials but rather from repeated exposures and environmental pressures. Antimicrobial stewardship programs often focus only on the level of care provided by individual institutions, not the broader healthcare community. For optimal impact on resistance and patient outcomes, stewardship efforts should involve collaboration and coordination across different levels of care within and across healthcare referral communities. Evaluating trends in antibiotic use and resistance helps identify numerous antimicrobial resistance threats and areas for improvement.

Below are links to education and resources to reduce the impact of antimicrobial resistance across the state of Indiana for Staphylococcus/Streptococcus, Extended Spectrum Beta-Lactamases (ESBLs), Carbapenem-resistant Enterobacterales (CRE) and those with allergies. Within these topics, you’ll find a range of resources such as overview of the resistance challenge, supporting data, specific disease state summaries, links to relevant published and more.

 

Staphylococcus/Streptococcus Resistance Concerns: Gram-positive bacteria. Staphylococcus species are commonly found on the skin and mucous membranes of humans and other animals. Some, such as Staphylococcus aureus, can cause a range of infections from minor skin conditions to serious diseases like pneumonia, endocarditis, and sepsis.

 

 

Extended Spectrum Beta-Lactamases (ESBLs) State Impact: By the early 2000’s, certain ESBLs gained carbapenem-hydrolyzing abilities, leading to carbapenemase-producing Enterobacterales (CRE) that render beta-lactam antibiotics ineffective. CRE infections pose significant treatment challenges, necessitating rapid identification and prevention of spread through stewardship efforts.

 

 

Carbapenem-resistant Enterobacterales (CRE) Resistance Challenges: CRE bacteria are concerning because they often exhibit resistance not only to carbapenems but also to multiple other classes of antibiotics. This resistance can severely limit treatment options, making infections caused by CRE difficult to manage and potentially life-threatening, especially in healthcare settings where vulnerable patients are at risk.

 

 

Diminishing the Allergy Impact: Overestimation of allergy has negatively impacted care, leading to poor outcomes,
increased adverse drug events (ADE), antibiotic resistance, antibiotic-associated infections. It is critical for healthcare practices to adapt a more rigorous approach to evaluating antibiotic allergies.

 

IMPORTANT DISCLAIMER—THIS WEBPAGE DOES NOT PROVIDE MEDICAL ADVICE

The information provided on this webpage is intended as general overview and background information. It is not intended to be, and should not be considered to be, medical advice or used in any way for the diagnosis or treatment of any specific medical condition. As to any specific medical condition, you should always seek the advice of a physician or other qualified health care provider. You also should not disregard professional medical advice given directly to you based on information contained on this webpage.